Chicago Med season 10 cast exit, premiere date, and more to know

Updated: Aug. 22, 2025 - Chicago Med was renewed in April when NBC confirmed that five out of the network's six Dick Wolf shows would be returning for the 2024-2025 TV season. Law and Order Organize Crime will be making the move to Peacock for its fifth season, so the franchise's Thursday line-up will look a tad different but at least the One Chicago shows are all sticking together.

What can we expect from the the medical drama's milestone season? Well, season 10 is set to come with changes as there's a new showrunner, a major cast exit, and some additions as well. Here's what you need to know!

Chicago Med season 10 premiere date

All three One Chicago shows will be back on Wednesday, Sept. 25. Chicago Med will premiere its new season in the 9 p.m. ET slot per usual. Next day streaming will be available on Peacock. As Hidden Remote reported previously, fans won't be dealing with yet another shortened season. NBC has greenlit full season orders for the franchise, so the medical drama will have a 22 episode count for season 10.

Allen MacDonald steps in as executive producer and showrunner

After nine seasons with the show, Diane Frolov and Andy Schneider have stepped down as co-showrunners. Allen MacDonald will now helm the series. MacDonald's credits include executive producer and co-showrunner of the Prime Video original Harlan Coben's Shelter and writer-producer on Body of Proof and CSI.

Dominic Rains is leaving Chicago Med

So far there is one significant cast exit that's been announced ahead of season 10. Dominic Rains won't be returning as a series regular. Deadline reports that there's no word on whether he'll make a guest appearance.

The door was opened for his departure in the season 9 finale when Dr. Crockett Marcel's refused to do a liver transplant after his young patient caught an infection. Despite the father's pleas, he stuck by his decision to cancel the planned surgery. The boy died and, in his grief, the father took his own life. Crockett was devastated and the situation also brought up memories of his daughter's loss. She had died of leukemia.

Rains made his debut as the emergency room surgeon back in season 5. He's sure to be missed.

Cast

Expected to return:

• Epatha Merkerson as Sharon Goodwin
• Marlyne Barrett as Maggie Lockwood
• Oliver Platt as Dr. Daniel Charles
• Steven Weber as Dr. Dean Archer
• Jessy Schram as Dr. Hannah Asher
• T.V. Caprio as Grace Song
• Alet Taylor as Liliana Wapnirarski
• Luke Mitchell as Dr. Mitch Ripley
• Ashlei Sharpe Chestnut as Naomi Howard

New cast members

Sara Ramos as Dr. Caitlin Lenox

Fans of The Bear will be familiar with Sara Ramos, though instead of playing an excellent front of house employee at a renowned restaurant, she's been cast as an ED Attending. Her character, Dr. Lenox, believes that Gaffney Medical needs to "get in shape" and she's the person to do it.

Darren Barnet as Dr. John Frost

Darren Barnet played a heartthrob on Never Have I Ever but in Chicago Med he'll be playing Dr. Frost, a pediatric resident with a secret. Sounds a bit ominous, to be honest, and intriguing.

We'll keep you posted as more news comes in about the new season. Stay tuned to Hidden Remote and follow us on X!