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Best Medicine has the potential to become Josh Charles's best TV role

The actor has had may other roles on television before the newest Fox hit.
BEST MEDICINE: Josh Charles in the "All the World's Ablaze" episode of BEST MEDICINE airing Tuesday, Jan 27 (8:00-9:00 PM ET/PT) on FOX.
BEST MEDICINE: Josh Charles in the "All the World's Ablaze" episode of BEST MEDICINE airing Tuesday, Jan 27 (8:00-9:00 PM ET/PT) on FOX. | © 2026 Fox Media LLC. CR: Francisco Roman/FOX.

Fox seemed to have the right formula for its new series, Best Medicine. The show is becoming a hit and was recently renewed for a second season. Series star Josh Charles is one of the main reasons why the show has started to resonate with audiences.

This is not the first television role the actor has been a part of. He has had several other roles that have been high profile and some not as well known.

Arguably his most famous television role was on The Good Wife, where he portrayed Will Gardner for the first five seasons. The role earned him two Emmy nominations. This, though, may not be his best role before starring in Best Medicine.

From 1998 to 2000, Charles starred on the first Aaron Sorkin series, Sports Night. The show may not have had staying power, but the work and show have garnered a cult following since it left the air. It also demonstrated Charles's ability to take on both dramatic and comedic roles at the same time, which may have led to his new role.

Best Medicine is considered by many to be both a comedy and a drama at the same time. The same could be said for Sports Night. Charles, playing a former drug addict turned sports personality, Dan Rydall, has many similarities to his role on the newer series.

The first time the new series starring Charles was advertised was during NFL football games airing on Fox. That may be a coincidence, but Charles had a starring voice role related to the league.

From 2011 to 2023, the actor provided the narration for the NFL Network series A Football Life. The show would highlight a different player or team in each episode. Charles had a very subtle way he spoke, which provided the perfect narration for each episode in the world of football.

As he takes his turn as a leading man on the Fox series, he could be turning in his best performance, but it does come after several other roles that gave him a chance to prove he could be a leading actor on a series. As the show finishes its first season run, it will be curious how he carries this into the next season and other work past the season finale.

In its first season, Charles has delivered an incredible performance, and there is a good chance this role could very well evolve into his best TV role yet. With a second season already ordered, we'll get to see how Best Medicine continues to cement its place in Charles's legendary career.

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